In the Mutant X universe, Typhoid Mary became one of Earth's Mightiest Heroes under unrevealed circumstances. Her team was tapped by President Graydon Creed to help enforce his executive order that all powered individuals must submit themselves to government custody for their own protection. This reality's Captain America refused to work for the government, and abandoned Mary and his Avengers teammates. They encountered each other again months later at a stand-off on the highly contested American / Canadian border. Captain America and his new mutant teammates the Six needed access to Canada to rescue their friends, but Black Widow's Avengers refused to let the "traitor" and his people through. In the fight that followed, Cap's buried super-soldier programming kicked him, giving him vast powers but an unstable mind. Typhoid Mary and the Avengers tried to fight him, but were atomized in a stray blast cast from his mind.