Pizer and his sentient skin were first mentioned in Excalibur (1st series) #87. A statue of the Skinless Man was seen in Uncanny X-Force (1st series) #18. In #22, the two were confirmed to be the same man, and tied to the Weapon Plus Program.
Pizer previously possessed mutant skin which was removed from his body by Otherworld and later converted into sentient, biting, mutant-killing bullets used by Fantomex and the Genoshan Magistrates.
Pizer's first name was revealed in the Marvel Handbooks.