In the Ultimate Universe, Ruth bat-Seraph was an agent of the Mossad. It is unknown if she was a mutant or superhuman. She was a victim of Doctor Faustus, a black market dealer of exotic data and tech operating out of Prague. Ruth’s head was mounted on his wall along with the heads of many other world intelligence agents who got too close to his business.
During the House of M, Sabra was a member of Magneto's mutant-operated S.H.I.E.L.D. She was added to the Red Guard when Sebastian Shaw and Wolverine prepared a counter-revolution to retake the formerly mutant-friendly nation of Santo Marco from Parker Robbins and his Sapiens gang. In the siege, Sabra and Shaw killed the Constrictor among other criminals. Many S.H.I.E.L.D. agents were reportedly killed when the giant Absorbing Man toppled, so her final fate is unknown.
On Battleworld, in the domain of Arcadia, there existed a team of heroes known as A-Force. Sabra was a member of this nearly-all female group of protectors, whose domain bordered the Shield wall that contained the threats to God Doom’s rule. Sabra and the women of A-Force rose to defend Battleworld when the Shield was breached, and fought against a horde of invading zombies from the lands beyond.
In X-Men: Millennial Visions, Sabra appeared alongside an international roster for the covert ops unit known as Weapon X. Apparently the field leader, she oversaw the likes of Russia’s Vanguard, Germany’s Maverick, England’s Spitfire, Japan’s Sunfire, and Canada’s Flashback. With the overabundance of mutants and super-heroes in the United States, a secret cabal backed by other nations decided they needed their own team to respond to threats and missions outside America. These agents were chosen not only for reliability, but also deniability and expendability. The ultimate goals of Sabra’s overseers were never revealed.