Legacy numbered series continued from Fantastic Four (3rd series), which ended #70. The creative team of Mark Waid & Mike Wieringo continued, followed by J. Michael Straczynski, Mark Millar and Jonathan Hickman.
Title was placed on hiatus following #588, after which it was replaced with FF (1st series), which ran for 12 issues. The title reverted to legacy numbering with #600 but only lasted an additional 11 issues before being replaced with Matt Fraction's Fantastic Four (4th series).